We Might Regret This follows Freya (Kyla Harris), a 30-something Canadian artist and tetraplegic, who moves to London to live with her new partner, Abe (Darren Boyd), a 50-something straight-laced lawyer. Due to her disability Freya requires round the clock assistance from a dedicated PA. After failing to find the right person, Freya hires her chaotic and impulsive best friend Jo (Elena Saurel) to take on the role. The show explores the complex, often messy boundaries between friendship, romance and caregiving.